The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function

Barnes et al. show that a bioactive lipid, lysophosphatidylserine, negatively influences T reg cell accumulation and activity through one of its receptors, GPR174. The authors speculate that GPR174 antagonism may be therapeutic for autoimmune diseases.

Bibliographic Details
Main Authors:	Barnes, Michael J., Li, Chien-Ming, Xu, Ying, An, Jinping, Huang, Yong, Cyster, Jason G.
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493414/

id	pubmed-4493414
recordtype	oai_dc
spelling	pubmed-44934142015-12-29 The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function Barnes, Michael J. Li, Chien-Ming Xu, Ying An, Jinping Huang, Yong Cyster, Jason G. Brief Definitive Report Barnes et al. show that a bioactive lipid, lysophosphatidylserine, negatively influences T reg cell accumulation and activity through one of its receptors, GPR174. The authors speculate that GPR174 antagonism may be therapeutic for autoimmune diseases. The Rockefeller University Press 2015-06-29 /pmc/articles/PMC4493414/ /pubmed/26077720 http://dx.doi.org/10.1084/jem.20141827 Text en © 2015 Barnes et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Barnes, Michael J. Li, Chien-Ming Xu, Ying An, Jinping Huang, Yong Cyster, Jason G.
spellingShingle	Barnes, Michael J. Li, Chien-Ming Xu, Ying An, Jinping Huang, Yong Cyster, Jason G. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
author_facet	Barnes, Michael J. Li, Chien-Ming Xu, Ying An, Jinping Huang, Yong Cyster, Jason G.
author_sort	Barnes, Michael J.
title	The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
title_short	The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
title_full	The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
title_fullStr	The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
title_full_unstemmed	The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
title_sort	lysophosphatidylserine receptor gpr174 constrains regulatory t cell development and function
description	Barnes et al. show that a bioactive lipid, lysophosphatidylserine, negatively influences T reg cell accumulation and activity through one of its receptors, GPR174. The authors speculate that GPR174 antagonism may be therapeutic for autoimmune diseases.
publisher	The Rockefeller University Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493414/
_version_	1613244628483440640

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function

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