The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
Barnes et al. show that a bioactive lipid, lysophosphatidylserine, negatively influences T reg cell accumulation and activity through one of its receptors, GPR174. The authors speculate that GPR174 antagonism may be therapeutic for autoimmune diseases.
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493414/ |