Structural and sequencing analysis of local target DNA recognition by MLV integrase

Structural and sequencing analysis of local target DNA recognition by MLV integrase

Target-site selection by retroviral integrase (IN) proteins profoundly affects viral pathogenesis. We describe the solution nuclear magnetic resonance structure of the Moloney murine leukemia virus IN (M-MLV) C-terminal domain (CTD) and a structural homology model of the catalytic core domain (CCD)....

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Bibliographic Details
Main Authors: Aiyer, Sriram, Rossi, Paolo, Malani, Nirav, Schneider, William M., Chandar, Ashwin, Bushman, Frederic D., Montelione, Gaetano T., Roth, Monica J.
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477651/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477651/

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