Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy

Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy

Expression of the tumor suppressor gene TUSC2 is reduced or absent in most lung cancers and is associated with worse overall survival. In this study, we restored TUSC2 gene expression in several wild type EGFR non-small cell lung cancer (NSCLC) cell lines resistant to the epidermal growth factor rec...

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Bibliographic Details
Main Authors: Dai, Bingbing, Yan, Shaoyu, Lara-Guerra, Humberto, Kawashima, Hiroyuki, Sakai, Ryo, Jayachandran, Gitanjali, Majidi, Mourad, Mehran, Reza, Wang, Jing, Bekele, B. Nebiyou, Baladandayuthapani, Veerabhadran, Yoo, Suk-Young, Wang, Ying, Ying, Jun, Meng, Feng, Ji, Lin, Roth, Jack A.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460038/

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