Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

Discovery of rare or low frequency variants in exome or genome data that are associated with complex traits often will require use of very large sample sizes to achieve adequate statistical power. For a fixed sample size, sequencing of individuals sampled from the tails of a phenotype distribution (...

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Main Authors: Emond, Mary J., Louie, Tin, Emerson, Julia, Chong, Jessica X., Mathias, Rasika A., Knowles, Michael R., Rieder, Mark J., Tabor, Holly K., Nickerson, Debbie A., Barnes, Kathleen C., GO, Lung, Gibson, Ronald L., Bamshad, Michael J.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457883/

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