Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

Quantitative single-molecule receptor dimerization assays show dimerization of IFNAR1 and IFNAR2 upon IFN treatment, and reveal the limiting role of IFNAR1 binding affinity in complex assembly and the regulatory role of USP18.

Bibliographic Details
Main Authors: Wilmes, Stephan, Beutel, Oliver, Li, Zhi, Francois-Newton, Véronique, Richter, Christian P., Janning, Dennis, Kroll, Cindy, Hanhart, Patrizia, Hötte, Katharina, You, Changjiang, Uzé, Gilles, Pellegrini, Sandra, Piehler, Jacob
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442803/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442803/

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