USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

Type I interferons (IFN) are cytokines that are rapidly secreted upon microbial infections and regulate all aspects of the immune response. In humans 15 type I IFN subtypes exist, of which IFN α2 and IFN β are used in the clinic for treatment of different pathologies. IFN α2 and IFN β are non redund...

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Bibliographic Details
Main Authors: François-Newton, Véronique, Magno de Freitas Almeida, Gabriel, Payelle-Brogard, Béatrice, Monneron, Danièle, Pichard-Garcia, Lydiane, Piehler, Jacob, Pellegrini, Sandra, Uzé, Gilles
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136508/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136508/

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