Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase
N-Myristoyltransferase (NMT) has been shown to be an attractive target for the development of novel therapeutic agents for the treatment of human African trypanosomiasis. A fragment library has been screened using NMR spectroscopy and the binding mode of the hits was confirmed by X-ray crystallogra...
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| Format: | Online |
| Language: | English |
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International Union of Crystallography
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427169/ |
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pubmed-4427169 |
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pubmed-44271692015-05-25 Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase Robinson, David A. Wyatt, Paul G. Molecular Parasitology N-Myristoyltransferase (NMT) has been shown to be an attractive target for the development of novel therapeutic agents for the treatment of human African trypanosomiasis. A fragment library has been screened using NMR spectroscopy and the binding mode of the hits was confirmed by X-ray crystallography using L. major NMT as a structural surrogate. International Union of Crystallography 2015-04-21 /pmc/articles/PMC4427169/ /pubmed/25945713 http://dx.doi.org/10.1107/S2053230X15003040 Text en © Robinson & Wyatt 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Robinson, David A. Wyatt, Paul G. |
| spellingShingle |
Robinson, David A. Wyatt, Paul G. Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| author_facet |
Robinson, David A. Wyatt, Paul G. |
| author_sort |
Robinson, David A. |
| title |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| title_short |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| title_full |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| title_fullStr |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| title_full_unstemmed |
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase |
| title_sort |
identification and structure solution of fragment hits against kinetoplastid n-myristoyltransferase |
| description |
N-Myristoyltransferase (NMT) has been shown to be an attractive target for the development of novel therapeutic agents for the treatment of human African trypanosomiasis. A fragment library has been screened using NMR spectroscopy and the binding mode of the hits was confirmed by X-ray crystallography using L. major NMT as a structural surrogate. |
| publisher |
International Union of Crystallography |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427169/ |
| _version_ |
1613221788307685376 |