Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase
N-Myristoyltransferase (NMT) has been shown to be an attractive target for the development of novel therapeutic agents for the treatment of human African trypanosomiasis. A fragment library has been screened using NMR spectroscopy and the binding mode of the hits was confirmed by X-ray crystallogra...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
International Union of Crystallography
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427169/ |