Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Crystal structures of N-myristoyltransferase with four distinct Leishmania-selective small-molecule inhibitors identify key binding-site residues and suggest strategies to design compounds with increased affinity.

Bibliographic Details
Main Authors: Brannigan, James A., Roberts, Shirley M., Bell, Andrew S., Hutton, Jennie A., Hodgkinson, Michael R., Tate, Edward W., Leatherbarrow, Robin J., Smith, Deborah F., Wilkinson, Anthony J.
Format: Online
Language:English
Published: International Union of Crystallography 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107925/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107925/

Similar Items