Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives

•We report the synthesis of tryptanthrin derivatives.•We report the activity of tryptanthrin derivatives against Plasmodium falciparum.•We discuss the potential of tryptanthrin derivatives as multi-stage drugs.•We recommend the formulation and testing of tryptanthrins in in vivo studies.

Bibliographic Details
Main Authors: Onambele, Liliane Abodo, Riepl, Herbert, Fischer, Rainer, Pradel, Gabriele, Prokop, Aram, Aminake, Makoah Nigel
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417838/
id pubmed-4417838
recordtype oai_dc
spelling pubmed-44178382015-05-06 Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives Onambele, Liliane Abodo Riepl, Herbert Fischer, Rainer Pradel, Gabriele Prokop, Aram Aminake, Makoah Nigel Article •We report the synthesis of tryptanthrin derivatives.•We report the activity of tryptanthrin derivatives against Plasmodium falciparum.•We discuss the potential of tryptanthrin derivatives as multi-stage drugs.•We recommend the formulation and testing of tryptanthrins in in vivo studies. Elsevier 2015-04-17 /pmc/articles/PMC4417838/ /pubmed/25949928 http://dx.doi.org/10.1016/j.ijpddr.2015.03.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Onambele, Liliane Abodo
Riepl, Herbert
Fischer, Rainer
Pradel, Gabriele
Prokop, Aram
Aminake, Makoah Nigel
spellingShingle Onambele, Liliane Abodo
Riepl, Herbert
Fischer, Rainer
Pradel, Gabriele
Prokop, Aram
Aminake, Makoah Nigel
Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
author_facet Onambele, Liliane Abodo
Riepl, Herbert
Fischer, Rainer
Pradel, Gabriele
Prokop, Aram
Aminake, Makoah Nigel
author_sort Onambele, Liliane Abodo
title Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
title_short Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
title_full Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
title_fullStr Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
title_full_unstemmed Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
title_sort synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
description •We report the synthesis of tryptanthrin derivatives.•We report the activity of tryptanthrin derivatives against Plasmodium falciparum.•We discuss the potential of tryptanthrin derivatives as multi-stage drugs.•We recommend the formulation and testing of tryptanthrins in in vivo studies.
publisher Elsevier
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417838/
_version_ 1613218600070414336

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