Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic co...

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Bibliographic Details
Main Authors: Schwartz, Brett D., Coster, Mark J., Skinner-Adams, Tina S., Andrews, Katherine T., White, Jonathan M., Davis, Rohan A.
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584354/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584354/

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