Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons

Mutation of the human gene superoxide dismutase (hSOD1) is associated with the fatal neurodegenerative disease familial amyotrophic lateral sclerosis (Lou Gehrig’s disease). Selective overexpression of hSOD1 in Drosophila motorneurons increases lifespan to 140% of normal. The current study was desig...

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Bibliographic Details
Main Authors: Petrosyan, Agavni, Hsieh, I-Hui, Phillips, John P., Saberi, Kourosh
Format: Online
Language:English
Published: Sociedade Brasileira de Genética 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415569/