INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

The pathogenic role of SOD1 mutations in amyotrophic lateral sclerosis (ALS) was investigated using a zebrafish disease model stably expressing the ALS-linked G93R mutation. In addition to the main pathological features of ALS shown by adult fish, we found remarkably precocious alterations in the de...

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Bibliographic Details
Main Authors: Benedetti, Lorena, Ghilardi, Anna, Rottoli, Elsa, De Maglie, Marcella, Prosperi, Laura, Perego, Carla, Baruscotti, Mirko, Bucchi, Annalisa, Del Giacco, Luca, Francolini, Maura
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832213/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832213/

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