CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibition on the pathways regulating proliferation a...

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Bibliographic Details
Main Authors: Huskey, Noelle E., Guo, Tingxia, Evason, Kimberley J., Momcilovic, Olga, Pardo, David, Creasman, Katelyn J., Judson, Robert L., Blelloch, Robert, Oakes, Scott A., Hebrok, Matthias, Goga, Andrei
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375943/

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