The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

Cell death on extended mitotic arrest is considered arguably most critical for the efficacy of microtubule-targeting agents (MTAs) in anticancer therapy. While the molecular machinery controlling mitotic arrest on MTA treatment, the spindle assembly checkpoint (SAC), appears well defined, the molecu...

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Bibliographic Details
Main Authors: Haschka, Manuel D., Soratroi, Claudia, Kirschnek, Susanne, Häcker, Georg, Hilbe, Richard, Geley, Stephan, Villunger, Andreas, Fava, Luca L.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423218/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423218/

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