DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

Noxa, a BH3-only pro-apoptotic BCL-2 family protein, causes apoptosis by specifically interacting with the anti-apoptotic protein MCL-1 to induce its proteasome-mediated degradation. We show here that the DNA damaging agents cisplatin and etoposide upregulate Noxa expression, which is required for t...

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Bibliographic Details
Main Authors: Nakajima, Wataru, Sharma, Kanika, Lee, June Young, Maxim, Nicolas T., Hicks, Mark A., Vu, Thien-Trang, Luu, Angela, Yeudall, W. Andrew, Tanaka, Nobuyuki, Harada, Hisashi
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095005/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095005/

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