Immune cells: more than simple carriers for systemic delivery of oncolytic viruses

Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat tumors. Addition of immune cell-based carriers of oncolytic viruses holds promise as a technique in whi...

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Main Authors:	Eisenstein, Samuel, Chen, Shu-Hsia, Pan, Ping-Ying
Format:	Online
Language:	English
Published:	Dove Medical Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354653/

id	pubmed-4354653
recordtype	oai_dc
spelling	pubmed-43546532015-03-10 Immune cells: more than simple carriers for systemic delivery of oncolytic viruses Eisenstein, Samuel Chen, Shu-Hsia Pan, Ping-Ying Review Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat tumors. Addition of immune cell-based carriers of oncolytic viruses holds promise as a technique in which oncolytic virus can be delivered directly to tumors in smaller and less toxic doses. Interestingly, the cell carriers themselves have also demonstrated antitumor effects, which can be augmented further by tailoring the appropriate oncolytic virus to the appropriate cell type. This review discusses the multiple factors that go into devising an effective, cell-based delivery system for oncolytic viruses. Dove Medical Press 2014-11-06 /pmc/articles/PMC4354653/ /pubmed/25767789 http://dx.doi.org/10.2147/OV.S47143 Text en © 2014 Eisenstein et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Eisenstein, Samuel Chen, Shu-Hsia Pan, Ping-Ying
spellingShingle	Eisenstein, Samuel Chen, Shu-Hsia Pan, Ping-Ying Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
author_facet	Eisenstein, Samuel Chen, Shu-Hsia Pan, Ping-Ying
author_sort	Eisenstein, Samuel
title	Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
title_short	Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
title_full	Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
title_fullStr	Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
title_full_unstemmed	Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
title_sort	immune cells: more than simple carriers for systemic delivery of oncolytic viruses
description	Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat tumors. Addition of immune cell-based carriers of oncolytic viruses holds promise as a technique in which oncolytic virus can be delivered directly to tumors in smaller and less toxic doses. Interestingly, the cell carriers themselves have also demonstrated antitumor effects, which can be augmented further by tailoring the appropriate oncolytic virus to the appropriate cell type. This review discusses the multiple factors that go into devising an effective, cell-based delivery system for oncolytic viruses.
publisher	Dove Medical Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354653/
_version_	1613197000285618176

Immune cells: more than simple carriers for systemic delivery of oncolytic viruses

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