Chimeric antigen receptor–engineered T cells as oncolytic virus carriers

The use of engineered T cells in adoptive transfer therapies has shown significant promise in treating hematological cancers. However, successes treating solid tumors are much less prevalent. Oncolytic viruses (OVs) have the capacity to induce specific lysis of tumor cells and indirectly impact tumo...

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Bibliographic Details
Main Authors: VanSeggelen, Heather, Tantalo, Daniela GM, Afsahi, Arya, Hammill, Joanne A, Bramson, Jonathan L
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782951/