Microevolution of Burkholderia pseudomallei during an Acute Infection

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei...

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Main Authors: Limmathurotsakul, Direk, Holden, Matthew T. G., Coupland, Paul, Price, Erin P., Chantratita, Narisara, Wuthiekanun, Vanaporn, Amornchai, Premjit, Parkhill, Julian, Peacock, Sharon J.
Format: Online
Language:English
Published: American Society for Microbiology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313173/