Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA met...

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Bibliographic Details
Main Authors: Acevedo, Nathalie, Reinius, Lovisa E., Greco, Dario, Gref, Anna, Orsmark-Pietras, Christina, Persson, Helena, Pershagen, Göran, Hedlin, Gunilla, Melén, Erik, Scheynius, Annika, Kere, Juha, Söderhäll, Cilla
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291244/

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