Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes raises several conceptual and safety issues. To a...

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Bibliographic Details
Main Authors: Qamar Saeed, Muhammad, Dufour, Noelle, Bartholmae, Cynthia, Sieranska, Urzula, Knopf, Malaika, Thierry, Eloïse, Thierry, Sylvain, Delelis, Olivier, Grandchamp, Nicolas, Pilet, Héloïse, Ravassard, Philippe, Massonneau, Julie, Pflumio, Françoise, von Kalle, Christof, Lachapelle, François, Bemelmans, Alexis-Pierre, Schmidt, Manfred, Serguera, Ché
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272407/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272407/

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