Retroviral Vectors: Post Entry Events and Genomic Alterations

by Nowrouzi, Ali, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred
Published 2011

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

by Alves, Sandro, Bode, Julia, Bemelmans, Alexis-Pierre, von Kalle, Christof, Cartier, Nathalie, Tews, Björn
Published 2016

Gene therapy for Wiskott-Aldrich Syndrome—Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis

by Braun, Christian Joerg, Witzel, Maximilian, Paruzynski, Anna, Boztug, Kaan, von Kalle, Christof, Schmidt, Manfred, Klein, Christoph
Published 2014

Analyzing the Number of Common Integration Sites of Viral Vectors – New Methods and Computer Programs

by Abel, Ulrich, Deichmann, Annette, Nowrouzi, Ali, Gabriel, Richard, Bartholomae, Cynthia C., Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred
Published 2011

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

by Biasco, Luca, Ambrosi, Alessandro, Pellin, Danilo, Bartholomae, Cynthia, Brigida, Immacolata, Roncarolo, Maria Grazia, Di Serio, Clelia, von Kalle, Christof, Schmidt, Manfred, Aiuti, Alessandro
Published 2011

Thymus-autonomous T cell development in the absence of progenitor import

by Martins, Vera C., Ruggiero, Eliana, Schlenner, Susan M., Madan, Vikas, Schmidt, Manfred, Fink, Pamela J., von Kalle, Christof, Rodewald, Hans-Reimer
Published 2012

So rare we need to hunt for them: reframing the ethical debate on incidental findings

by Schuol, Sebastian, Schickhardt, Christoph, Wiemann, Stefan, Bartram, Claus R., Tanner, Klaus, Eils, Roland, Meder, Benjamin, Richter, Daniela, Glimm, Hanno, von Kalle, Christof, Winkler, Eva C.
Published 2015

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

by Hoffmann, Katrin, Ganten, Tom, Gotthardtp, Daniel, Radeleff, Boris, Settmacher, Utz, Kollmar, Otto, Nadalin, Silvio, Karapanagiotou-Schenkel, Irini, von Kalle, Christof, Jäger, Dirk, Büchler, Markus W, Schemmer, Peter
Published 2015

Real-Time Definition of Non-Randomness in the Distribution of Genomic Events

by Abel, Ulrich, Deichmann, Annette, Bartholomae, Cynthia, Schwarzwaelder, Kerstin, Glimm, Hanno, Howe, Steven, Thrasher, Adrian, Garrigue, Alexandrine, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Fischer, Alain, Jaeger, Dirk, von Kalle, Christof, Schmidt, Manfred
Published 2007

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

by Ranzani, Marco, Cesana, Daniela, Bartholomae, Cynthia C., Sanvito, Francesca, Pala, Mauro, Benedicenti, Fabrizio, Gallina, Pierangela, Sergi, Lucia Sergi, Merella, Stefania, Bulfone, Alessandro, Doglioni, Claudio, von Kalle, Christof, Kim, Yoon Jun, Schmidt, Manfred, Tonon, Giovanni, Naldini, Luigi, Montini, Eugenio
Published 2013

High-resolution analysis of the human T-cell receptor repertoire

by Ruggiero, Eliana, Nicolay, Jan P., Fronza, Raffaele, Arens, Anne, Paruzynski, Anna, Nowrouzi, Ali, Ürenden, Gökçe, Lulay, Christina, Schneider, Sven, Goerdt, Sergij, Glimm, Hanno, Krammer, Peter H., Schmidt, Manfred, von Kalle, Christof
Published 2015

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

by Sundarasetty, Bala Sai, Kloess, Stephan, Oberschmidt, Olaf, Naundorf, Sonja, Kuehlcke, Klaus, Daenthanasanmak, Anusara, Gerasch, Laura, Figueiredo, Constanca, Blasczyk, Rainer, Ruggiero, Eliana, Fronza, Raffaele, Schmidt, Manfred, von Kalle, Christof, Rothe, Michael, Ganser, Arnold, Koehl, Ulrike, Stripecke, Renata
Published 2015

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

by Giordano, Frank A, Appelt, Jens-Uwe, Link, Barbara, Gerdes, Sebastian, Lehrer, Christina, Scholz, Simone, Paruzynski, Anna, Roeder, Ingo, Wenz, Frederik, Glimm, Hanno, von Kalle, Christof, Grez, Manuel, Schmidt, Manfred, Laufs, Stephanie
Published 2015

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

by Qamar Saeed, Muhammad, Dufour, Noelle, Bartholmae, Cynthia, Sieranska, Urzula, Knopf, Malaika, Thierry, Eloïse, Thierry, Sylvain, Delelis, Olivier, Grandchamp, Nicolas, Pilet, Héloïse, Ravassard, Philippe, Massonneau, Julie, Pflumio, Françoise, von Kalle, Christof, Lachapelle, François, Bemelmans, Alexis-Pierre, Schmidt, Manfred, Serguera, Ché
Published 2014

Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

by Hematti, Peiman, Hong, Bum-Kee, Ferguson, Cole, Adler, Rima, Hanawa, Hideki, Sellers, Stephanie, Holt, Ingeborg E, Eckfeldt, Craig E, Sharma, Yugal, Schmidt, Manfred, von Kalle, Christof, Persons, Derek A, Billings, Eric M, Verfaillie, Catherine M, Nienhuis, Arthur W, Wolfsberg, Tyra G, Dunbar, Cynthia E, Calmels, Boris
Published 2004

Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk

by Mátrai, Janka, Cantore, Alessio, Bartholomae, Cynthia C, Annoni, Andrea, Wang, Wei, Acosta-Sanchez, Abel, Samara-Kuko, Ermira, De Waele, Liesbeth, Ma, Ling, Genovese, Pietro, Damo, Martina, Arens, Anne, Goudy, Kevin, Nichols, Timothy C, von Kalle, Christof, Chuah, Marinee K L, Roncarolo, Maria Grazia, Schmidt, Manfred, VandenDriessche, Thierry, Naldini, Luigi
Published 2011

Preclinical Safety and Efficacy of Human CD34+ Cells Transduced With Lentiviral Vector for the Treatment of Wiskott-Aldrich Syndrome

by Scaramuzza, Samantha, Biasco, Luca, Ripamonti, Anna, Castiello, Maria C, Loperfido, Mariana, Draghici, Elena, Hernandez, Raisa J, Benedicenti, Fabrizio, Radrizzani, Marina, Salomoni, Monica, Ranzani, Marco, Bartholomae, Cynthia C, Vicenzi, Elisa, Finocchi, Andrea, Bredius, Robbert, Bosticardo, Marita, Schmidt, Manfred, von Kalle, Christof, Montini, Eugenio, Biffi, Alessandra, Roncarolo, Maria G, Naldini, Luigi, Villa, Anna, Aiuti, Alessandro
Published 2013

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

by Gröschel, Stefan, Bommer, Martin, Hutter, Barbara, Budczies, Jan, Bonekamp, David, Heining, Christoph, Horak, Peter, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Geörg, Christina, Richter, Daniela, Pfarr, Nicole, Pfütze, Katrin, Wolf, Stephan, Schirmacher, Peter, Jäger, Dirk, von Kalle, Christof, Brors, Benedikt, Glimm, Hanno, Weichert, Wilko, Stenzinger, Albrecht, Fröhling, Stefan
Published 2016

Preclinical Evaluation of Efficacy and Safety of an Improved Lentiviral Vector for the Treatment of β-Thalassemia and Sickle Cell Disease

by Negre, Olivier, Bartholomae, Cynthia, Beuzard, Yves, Cavazzana, Marina, Christiansen, Lauryn, Courne, Céline, Deichmann, Annette, Denaro, Maria, de Dreuzy, Edouard, Finer, Mitchell, Fronza, Raffaele, Gillet-Legrand, Béatrix, Joubert, Christophe, Kutner, Robert, Leboulch, Philippe, Maouche, Leïla, Paulard, Anaïs, Pierciey, Francis J., Rothe, Michael, Ryu, Byoung, Schmidt, Manfred, von Kalle, Christof, Payen, Emmanuel, Veres, Gabor
Published 2015

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV

by Daenthanasanmak, Anusara, Salguero, Gustavo, Sundarasetty, Bala Sai, Waskow, Claudia, Cosgun, Kadriye Nehir, Guzman, Carlos A, Riese, Peggy, Gerasch, Laura, Schneider, Andreas, Ingendoh, Alexandra, Messerle, Martin, Gabaev, Ildar, Woelk, Benno, Ruggiero, Eliana, Schmidt, Manfred, von Kalle, Christof, Figueiredo, Constanca, Eiz-Vesper, Britta, von Kaisenberg, Constantin, Ganser, Arnold, Stripecke, Renata
Published 2015