Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Hybrid Lentivirus-phiC31-int-NLS Vector Allows Site-Specific Recombination in Murine and Human Cells but Induces DNA Damage

Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV) is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vecto...

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Bibliographic Details
Main Authors: Grandchamp, Nicolas, Altémir, Dorothée, Philippe, Stéphanie, Ursulet, Suzanna, Pilet, Héloïse, Serre, Marie-Claude, Lenain, Aude, Serguera, Che, Mallet, Jacques, Sarkis, Chamsy
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067480/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067480/

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