Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73)
Alternative splicing of human NT5E generates CD73S, an endoplasmic reticulum–associated and dimerization-deficient glycoprotein that lacks enzymatic activity. CD73S functions as a negative regulator of canonical CD73 by promoting its proteasomal degradation, which may have significance in chronic li...
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The American Society for Cell Biology
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263446/ |
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pubmed-42634462015-03-02 Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) Snider, Natasha T. Altshuler, Peter J. Wan, Shanshan Welling, Theodore H. Cavalcoli, James Omary, M. Bishr Articles Alternative splicing of human NT5E generates CD73S, an endoplasmic reticulum–associated and dimerization-deficient glycoprotein that lacks enzymatic activity. CD73S functions as a negative regulator of canonical CD73 by promoting its proteasomal degradation, which may have significance in chronic liver disease and liver cancer. The American Society for Cell Biology 2014-12-15 /pmc/articles/PMC4263446/ /pubmed/25298403 http://dx.doi.org/10.1091/mbc.E14-06-1167 Text en © 2014 Snider et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Snider, Natasha T. Altshuler, Peter J. Wan, Shanshan Welling, Theodore H. Cavalcoli, James Omary, M. Bishr |
| spellingShingle |
Snider, Natasha T. Altshuler, Peter J. Wan, Shanshan Welling, Theodore H. Cavalcoli, James Omary, M. Bishr Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| author_facet |
Snider, Natasha T. Altshuler, Peter J. Wan, Shanshan Welling, Theodore H. Cavalcoli, James Omary, M. Bishr |
| author_sort |
Snider, Natasha T. |
| title |
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| title_short |
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| title_full |
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| title_fullStr |
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| title_full_unstemmed |
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73) |
| title_sort |
alternative splicing of human nt5e in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (cd73) |
| description |
Alternative splicing of human NT5E generates CD73S, an endoplasmic reticulum–associated and dimerization-deficient glycoprotein that lacks enzymatic activity. CD73S functions as a negative regulator of canonical CD73 by promoting its proteasomal degradation, which may have significance in chronic liver disease and liver cancer. |
| publisher |
The American Society for Cell Biology |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263446/ |
| _version_ |
1613166564927864832 |