Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73)

Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73)

Alternative splicing of human NT5E generates CD73S, an endoplasmic reticulum–associated and dimerization-deficient glycoprotein that lacks enzymatic activity. CD73S functions as a negative regulator of canonical CD73 by promoting its proteasomal degradation, which may have significance in chronic li...

Full description

Bibliographic Details
Main Authors: Snider, Natasha T., Altshuler, Peter J., Wan, Shanshan, Welling, Theodore H., Cavalcoli, James, Omary, M. Bishr
Format: Online
Language:English
Published: The American Society for Cell Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263446/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263446/

Similar Items