Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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Bibliographic Details
Main Authors: Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263144/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263144/

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