Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk

SphK1 is known to play a role in tumor progression, resistance to radiochemotherapy, and migration patterns. As the overall survival rates of squamous cell carcinoma of the head and neck (HNSCC) remain poor due to limitations in surgery and irradiation and chemotherapy resistance, SphK1 is an import...

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Bibliographic Details
Main Authors: Schiefler, Carlotta, Piontek, Guido, Doescher, Johannes, Schuettler, Dominik, Mißlbeck, Martin, Rudelius, Martina, Haug, Anna, Reiter, Rudolf, Brockhoff, Gero, Pickhard, Anja
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259444/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259444/

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