Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer

by Savić, Radoslav, He, Xingxuan, Fiel, Isabel, Schuchman, Edward H.
Published 2013

Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI

by Eliyahu, Efrat, Wolfson, Theodore, Ge, Yi, Jepsen, Karl J., Schuchman, Edward H., Simonaro, Calogera M.
Published 2011

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

by De Maria, Ruggero, Rippo, Maria Rita, Schuchman, Edward H., Testi, Roberto
Published 1998

Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

by Frohbergh, Michael, Ge, Yi, Meng, Fanli, Karabul, Nesrin, Solyom, Alexander, Lai, Alon, Iatridis, James, Schuchman, Edward H., Simonaro, Calogera M.
Published 2014

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

by Haimovitz-Friedman, Adriana, Cordon-Cardo, Carlos, Bayoumy, Shariff, Garzotto, Mark, McLoughlin, Maureen, Gallily, Ruth, Edwards, Carl K., Schuchman, Edward H., Fuks, Zvi, Kolesnick, Richard
Published 1997

Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

by Schuchman, Edward H., Ge, Yi, Lai, Alon, Borisov, Yury, Faillace, Meghan, Eliyahu, Efrat, He, Xingxuan, Iatridis, James, Vlassara, Helen, Striker, Gary, Simonaro, Calogera M.
Published 2013

Inhibition of GM3 Synthase Attenuates Neuropathology of Niemann-Pick Disease Type C by Affecting Sphingolipid Metabolism

by Lee, Hyun, Lee, Jong Kil, Bae, Yong Chul, Yang, Song Hyun, Okino, Nozomu, Schuchman, Edward H., Yamashita, Tadashi, Bae, Jae-sung, Jin, Hee Kyung
Published 2014

Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

by Arroyo, Ana I, Camoletto, Paola G, Morando, Laura, Sassoe-Pognetto, Marco, Giustetto, Maurizio, Van Veldhoven, Paul P, Schuchman, Edward H, Ledesma, Maria D
Published 2014

Acid Sphingomyelinase Mediates Oxidized-LDL Induced Apoptosis in Macrophage via Endoplasmic Reticulum Stress

by Zhao, Min, Pan, Wei, Shi, Rui-zheng, Bai, Yong-ping, You, Bo-yang, Zhang, Kai, Fu, Qiong-mei, Schuchman, Edward H., He, Xing-xuan, Zhang, Guo-gang
Published 2016

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

by Lee, Jong Kil, Jin, Hee Kyung, Park, Min Hee, Kim, Bo-ra, Lee, Phil Hyu, Nakauchi, Hiromitsu, Carter, Janet E., He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung
Published 2014

Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

by Simonaro, Calogera M., Sachot, Sylvain, Ge, Yi, He, Xingxuan, DeAngelis, Victor A., Eliyahu, Efrat, Leong, Daniel J., Sun, Hui B., Mason, Jeffrey B., Haskins, Mark E., Richardson, Dean W., Schuchman, Edward H.
Published 2013

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

by Pewzner-Jung, Yael, Tavakoli Tabazavareh, Shaghayegh, Grassmé, Heike, Becker, Katrin Anne, Japtok, Lukasz, Steinmann, Jörg, Joseph, Tammar, Lang, Stephan, Tuemmler, Burkhard, Schuchman, Edward H, Lentsch, Alex B, Kleuser, Burkhard, Edwards, Michael J, Futerman, Anthony H, Gulbins, Erich
Published 2014

Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs

by Simonaro, Calogera M., Tomatsu, Shunji, Sikora, Tracy, Kubaski, Francyne, Frohbergh, Michael, Guevara, Johana M., Wang, Raymond Y., Vera, Moin, Kang, Jennifer L., Smith, Lachlan J., Schuchman, Edward H., Haskins, Mark E.
Published 2016

Systemic ceramide accumulation leads to severe and varied pathological consequences

by Alayoubi, Abdulfatah M, Wang, James C M, Au, Bryan C Y, Carpentier, Stéphane, Garcia, Virginie, Dworski, Shaalee, El-Ghamrasni, Samah, Kirouac, Kevin N, Exertier, Mathilde J, Xiong, Zi Jian, Privé, Gilbert G, Simonaro, Calogera M, Casas, Josefina, Fabrias, Gemma, Schuchman, Edward H, Turner, Patricia V, Hakem, Razqallah, Levade, Thierry, Medin, Jeffrey A
Published 2013

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

by Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Published 2014