Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

This study shows how chronic stress and heat shock response exacerbate the phenotype in protein misfolding diseases by triggering a Maladaptive Stress Response; this pathway represents a promising therapeutic target for multiple genetic disorders.

Bibliographic Details
Main Authors: Roth, Daniela Martino, Hutt, Darren M., Tong, Jiansong, Bouchecareilh, Marion, Wang, Ning, Seeley, Theo, Dekkers, Johanna F., Beekman, Jeffrey M., Garza, Dan, Drew, Lawrence, Masliah, Eliezer, Morimoto, Richard I., Balch, William E.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236052/
id pubmed-4236052
recordtype oai_dc
spelling pubmed-42360522014-11-21 Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding Roth, Daniela Martino Hutt, Darren M. Tong, Jiansong Bouchecareilh, Marion Wang, Ning Seeley, Theo Dekkers, Johanna F. Beekman, Jeffrey M. Garza, Dan Drew, Lawrence Masliah, Eliezer Morimoto, Richard I. Balch, William E. Research Article This study shows how chronic stress and heat shock response exacerbate the phenotype in protein misfolding diseases by triggering a Maladaptive Stress Response; this pathway represents a promising therapeutic target for multiple genetic disorders. Public Library of Science 2014-11-18 /pmc/articles/PMC4236052/ /pubmed/25406061 http://dx.doi.org/10.1371/journal.pbio.1001998 Text en © 2014 Roth et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Roth, Daniela Martino
Hutt, Darren M.
Tong, Jiansong
Bouchecareilh, Marion
Wang, Ning
Seeley, Theo
Dekkers, Johanna F.
Beekman, Jeffrey M.
Garza, Dan
Drew, Lawrence
Masliah, Eliezer
Morimoto, Richard I.
Balch, William E.
spellingShingle Roth, Daniela Martino
Hutt, Darren M.
Tong, Jiansong
Bouchecareilh, Marion
Wang, Ning
Seeley, Theo
Dekkers, Johanna F.
Beekman, Jeffrey M.
Garza, Dan
Drew, Lawrence
Masliah, Eliezer
Morimoto, Richard I.
Balch, William E.
Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
author_facet Roth, Daniela Martino
Hutt, Darren M.
Tong, Jiansong
Bouchecareilh, Marion
Wang, Ning
Seeley, Theo
Dekkers, Johanna F.
Beekman, Jeffrey M.
Garza, Dan
Drew, Lawrence
Masliah, Eliezer
Morimoto, Richard I.
Balch, William E.
author_sort Roth, Daniela Martino
title Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
title_short Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
title_full Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
title_fullStr Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
title_full_unstemmed Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding
title_sort modulation of the maladaptive stress response to manage diseases of protein folding
description This study shows how chronic stress and heat shock response exacerbate the phenotype in protein misfolding diseases by triggering a Maladaptive Stress Response; this pathway represents a promising therapeutic target for multiple genetic disorders.
publisher Public Library of Science
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236052/
_version_ 1613158082310832128

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