This study shows how chronic stress and heat shock response exacerbate the phenotype in protein misfolding diseases by triggering a Maladaptive Stress Response; this pathway represents a promising therapeutic target for multiple genetic disorders.
Bibliographic Details
| Main Authors: |
Roth, Daniela Martino,
Hutt, Darren M.,
Tong, Jiansong,
Bouchecareilh, Marion,
Wang, Ning,
Seeley, Theo,
Dekkers, Johanna F.,
Beekman, Jeffrey M.,
Garza, Dan,
Drew, Lawrence,
Masliah, Eliezer,
Morimoto, Richard I.,
Balch, William E. |
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| Format: | Online
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| Language: | English |
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| Published: |
Public Library of Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236052/
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