Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

This study shows how chronic stress and heat shock response exacerbate the phenotype in protein misfolding diseases by triggering a Maladaptive Stress Response; this pathway represents a promising therapeutic target for multiple genetic disorders.

Bibliographic Details
Main Authors: Roth, Daniela Martino, Hutt, Darren M., Tong, Jiansong, Bouchecareilh, Marion, Wang, Ning, Seeley, Theo, Dekkers, Johanna F., Beekman, Jeffrey M., Garza, Dan, Drew, Lawrence, Masliah, Eliezer, Morimoto, Richard I., Balch, William E.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236052/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236052/

Similar Items