HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

Che-1/AATF is an RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in response to DNA damage. We have previously demonstrated that following apoptotic induction, Che-1 protein levels are downregulated through it...

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Bibliographic Details
Main Authors: De Nicola, F, Catena, V, Rinaldo, C, Bruno, T, Iezzi, S, Sorino, C, Desantis, A, Camerini, S, Crescenzi, M, Floridi, A, Passananti, C, Soddu, S, Fanciulli, M
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225224/

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