MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

The p53 inhibitor, MDM4 (MDMX) is a cytoplasmic protein with p53-activating function under DNA damage conditions. Particularly, MDM4 promotes phosphorylation of p53 at Ser46, a modification that precedes different p53 activities. We investigated the mechanism by which MDM4 promotes this p53 modifica...

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Bibliographic Details
Main Authors: Mancini, F, Pieroni, L, Monteleone, V, Lucà, R, Fici, L, Luca, E, Urbani, A, Xiong, S, Soddu, S, Masetti, R, Lozano, G, Pontecorvi, A, Moretti, F
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717155/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717155/

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