HIPK family kinases bind and regulate the function of the CCR4-NOT complex

HIPK family kinases bind and regulate the function of the CCR4-NOT complex

Down-regulation of the HIPK interactor CNOT2 leads to reduced HIPK2 protein levels, identifying the CCR4-NOT complex as a new regulator of HIPK2 abundance. Functional assays reveal that HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay, thus extending the regulatory potential of these kinases to t...

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Bibliographic Details
Main Authors: Rodriguez-Gil, Alfonso, Ritter, Olesja, Hornung, Juliane, Stekman, Hilda, Krüger, Marcus, Braun, Thomas, Kremmer, Elisabeth, Kracht, Michael, Schmitz, M. Lienhard
Format: Online
Language:English
Published: The American Society for Cell Biology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907730/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907730/

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