Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data

Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data

Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numbers throughout the genome, and an assessment of whether identified mutation variant allele...

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Bibliographic Details
Main Authors: Lönnstedt, Ingrid M, Caramia, Franco, Li, Jason, Fumagalli, Debora, Salgado, Roberto, Rowan, Andrew, Salm, Max, Kanu, Nnennaya, Savas, Peter, Horswell, Stuart, Gade, Stephan, Loibl, Sibylle, Neven, Patrick, Sotiriou, Christos, Swanton, Charles, Loi, Sherene, Speed, Terence P
Format: Online
Language:English
Published: BioMed Central 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220069/

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