Aneuploid yeast strains exhibit defects in cell growth and passage through START

Aneuploidy causes cell proliferation defects in budding yeast, with many aneuploid strains exhibiting a G1 delay. This study shows that the G1 delay in aneuploid budding yeast is caused by a growth defect and delayed passage through START due to delayed G1 cyclin accumulation.

Bibliographic Details
Main Authors: Thorburn, Rebecca R., Gonzalez, Christian, Brar, Gloria A., Christen, Stefan, Carlile, Thomas M., Ingolia, Nicholas T., Sauer, Uwe, Weissman, Jonathan S., Amon, Angelika
Format: Online
Language:English
Published: The American Society for Cell Biology 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639041/