Double-focusing mixing jet for XFEL study of chemical kinetics

A novel method for time-resolved study of chemical kinetics using a windowless mixing jet at an X-ray free-electron laser (XFEL) is described and demonstrated. The short mixing time gives a time resolution of about 250 µs; the design introduces controllable delays after the initiation of a chemical...

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Main Authors: Wang, Dingjie, Weierstall, Uwe, Pollack, Lois, Spence, John
Format: Online
Language:English
Published: International Union of Crystallography 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211133/
id pubmed-4211133
recordtype oai_dc
spelling pubmed-42111332014-11-03 Double-focusing mixing jet for XFEL study of chemical kinetics Wang, Dingjie Weierstall, Uwe Pollack, Lois Spence, John Short Communications A novel method for time-resolved study of chemical kinetics using a windowless mixing jet at an X-ray free-electron laser (XFEL) is described and demonstrated. The short mixing time gives a time resolution of about 250 µs; the design introduces controllable delays after the initiation of a chemical reaction, allowing the possibility for detection of transient structures by an XFEL beam pulse. Applications may include time-resolved enzyme–substrate imaging or protein folding. International Union of Crystallography 2014-10-07 /pmc/articles/PMC4211133/ /pubmed/25343806 http://dx.doi.org/10.1107/S160057751401858X Text en © Dingjie Wang et al. 2014 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wang, Dingjie
Weierstall, Uwe
Pollack, Lois
Spence, John
spellingShingle Wang, Dingjie
Weierstall, Uwe
Pollack, Lois
Spence, John
Double-focusing mixing jet for XFEL study of chemical kinetics
author_facet Wang, Dingjie
Weierstall, Uwe
Pollack, Lois
Spence, John
author_sort Wang, Dingjie
title Double-focusing mixing jet for XFEL study of chemical kinetics
title_short Double-focusing mixing jet for XFEL study of chemical kinetics
title_full Double-focusing mixing jet for XFEL study of chemical kinetics
title_fullStr Double-focusing mixing jet for XFEL study of chemical kinetics
title_full_unstemmed Double-focusing mixing jet for XFEL study of chemical kinetics
title_sort double-focusing mixing jet for xfel study of chemical kinetics
description A novel method for time-resolved study of chemical kinetics using a windowless mixing jet at an X-ray free-electron laser (XFEL) is described and demonstrated. The short mixing time gives a time resolution of about 250 µs; the design introduces controllable delays after the initiation of a chemical reaction, allowing the possibility for detection of transient structures by an XFEL beam pulse. Applications may include time-resolved enzyme–substrate imaging or protein folding.
publisher International Union of Crystallography
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211133/
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