Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

•TNF-α induces neuronal loss in culture without neuronal necrosis or apoptosis.•TNF-α induces microglial phagocytosis, and the neuronal loss requires microglia.•Neuronal loss requires the microglial vitronectin receptor, P2Y6 receptor and MFG-E8.•Blocking these phagocytic receptors leaves viable neu...

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Bibliographic Details
Main Authors:	Neniskyte, Urte, Vilalta, Anna, Brown, Guy C.
Format:	Online
Language:	English
Published:	Elsevier Science B.V 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158418/

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