Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency.

Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency.

To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyeth...

Full description

Bibliographic Details
Main Authors: Tsutsumi, Y., Tsunoda, S., Kamada, H., Kihira, T., Nakagawa, S., Kaneda, Y., Kanamori, T., Mayumi, T.
Format: Online
Language:English
Published: Nature Publishing Group 1996
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077111/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077111/

Similar Items