Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
•TNF-α induces neuronal loss in culture without neuronal necrosis or apoptosis.•TNF-α induces microglial phagocytosis, and the neuronal loss requires microglia.•Neuronal loss requires the microglial vitronectin receptor, P2Y6 receptor and MFG-E8.•Blocking these phagocytic receptors leaves viable neu...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science B.V
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158418/ |