Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell ad...

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Main Authors:	Cardozo, Marcos Julián, Sánchez-Arrones, Luisa, Sandonis, África, Sánchez-Camacho, Cristina, Gestri, Gaia, Wilson, Stephen W., Guerrero, Isabel, Bovolenta, Paola
Format:	Online
Language:	English
Published:	Nature Pub. Group 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102123/

id	pubmed-4102123
recordtype	oai_dc
spelling	pubmed-41021232014-07-17 Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle Cardozo, Marcos Julián Sánchez-Arrones, Luisa Sandonis, África Sánchez-Camacho, Cristina Gestri, Gaia Wilson, Stephen W. Guerrero, Isabel Bovolenta, Paola Article Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This receptor complex binds Hh and enhances signalling activation, indicating that Cdon positively regulates the pathway. Here we show that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with a complementary pattern, Cdon acts as a negative Hh signalling regulator. Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hh protein, thereby limiting its dispersion. This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye. Nature Pub. Group 2014-07-08 /pmc/articles/PMC4102123/ /pubmed/25001599 http://dx.doi.org/10.1038/ncomms5272 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Cardozo, Marcos Julián Sánchez-Arrones, Luisa Sandonis, África Sánchez-Camacho, Cristina Gestri, Gaia Wilson, Stephen W. Guerrero, Isabel Bovolenta, Paola
spellingShingle	Cardozo, Marcos Julián Sánchez-Arrones, Luisa Sandonis, África Sánchez-Camacho, Cristina Gestri, Gaia Wilson, Stephen W. Guerrero, Isabel Bovolenta, Paola Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
author_facet	Cardozo, Marcos Julián Sánchez-Arrones, Luisa Sandonis, África Sánchez-Camacho, Cristina Gestri, Gaia Wilson, Stephen W. Guerrero, Isabel Bovolenta, Paola
author_sort	Cardozo, Marcos Julián
title	Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_short	Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_full	Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_fullStr	Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_full_unstemmed	Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_sort	cdon acts as a hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
description	Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This receptor complex binds Hh and enhances signalling activation, indicating that Cdon positively regulates the pathway. Here we show that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with a complementary pattern, Cdon acts as a negative Hh signalling regulator. Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hh protein, thereby limiting its dispersion. This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye.
publisher	Nature Pub. Group
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102123/
_version_	1613115271683244032

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

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