Modelling Proteasome and Proteasome Regulator Activities

Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these proteins are degraded have a profound impact on immune sy...

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Main Authors:	Liepe, Juliane, Holzhütter, Herman-Georg, Kloetzel, Peter M., Stumpf, Michael P. H., Mishto, Michele
Format:	Online
Language:	English
Published:	MDPI 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101499/

id	pubmed-4101499
recordtype	oai_dc
spelling	pubmed-41014992014-07-28 Modelling Proteasome and Proteasome Regulator Activities Liepe, Juliane Holzhütter, Herman-Georg Kloetzel, Peter M. Stumpf, Michael P. H. Mishto, Michele Review Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these proteins are degraded have a profound impact on immune system function and many cellular metabolic processes. The regulation of proteasome activity involves different mechanisms, such as the substitution of the catalytic subunits, the binding of regulatory complexes to proteasome gates and the proteasome conformational modifications triggered by the target protein itself. Mathematical models are invaluable in the analysis; and potentially allow us to predict the complex interactions of proteasome regulatory mechanisms and the final outcomes of the protein degradation rate and MHC class I epitope generation. The pioneering attempts that have been made to mathematically model proteasome activity, cleavage preference variation and their modification by one of the regulatory mechanisms are reviewed here. MDPI 2014-06-20 /pmc/articles/PMC4101499/ /pubmed/24970232 http://dx.doi.org/10.3390/biom4020585 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Liepe, Juliane Holzhütter, Herman-Georg Kloetzel, Peter M. Stumpf, Michael P. H. Mishto, Michele
spellingShingle	Liepe, Juliane Holzhütter, Herman-Georg Kloetzel, Peter M. Stumpf, Michael P. H. Mishto, Michele Modelling Proteasome and Proteasome Regulator Activities
author_facet	Liepe, Juliane Holzhütter, Herman-Georg Kloetzel, Peter M. Stumpf, Michael P. H. Mishto, Michele
author_sort	Liepe, Juliane
title	Modelling Proteasome and Proteasome Regulator Activities
title_short	Modelling Proteasome and Proteasome Regulator Activities
title_full	Modelling Proteasome and Proteasome Regulator Activities
title_fullStr	Modelling Proteasome and Proteasome Regulator Activities
title_full_unstemmed	Modelling Proteasome and Proteasome Regulator Activities
title_sort	modelling proteasome and proteasome regulator activities
description	Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these proteins are degraded have a profound impact on immune system function and many cellular metabolic processes. The regulation of proteasome activity involves different mechanisms, such as the substitution of the catalytic subunits, the binding of regulatory complexes to proteasome gates and the proteasome conformational modifications triggered by the target protein itself. Mathematical models are invaluable in the analysis; and potentially allow us to predict the complex interactions of proteasome regulatory mechanisms and the final outcomes of the protein degradation rate and MHC class I epitope generation. The pioneering attempts that have been made to mathematically model proteasome activity, cleavage preference variation and their modification by one of the regulatory mechanisms are reviewed here.
publisher	MDPI
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101499/
_version_	1613115010923364352

Modelling Proteasome and Proteasome Regulator Activities

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