PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect

PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect

Pigment epithelium-derived factor (PEDF) has many biological activities. But it's not known whether PEDF and its functional peptides could protect against hypoxia-induced cell death and the mechanisms are still unclear. We used cultured H9c2 cells and primary cardiomyocytes to show that apoptos...

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Bibliographic Details
Main Authors: Gao, Xiao, Zhang, Hao, Zhuang, Wei, Yuan, Guangda, Sun, Teng, Jiang, Xia, Zhou, Zhongxin, Yuan, Honghua, Zhang, Zhongming, Dong, Hongyan
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092347/

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