The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of mod...

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Main Authors:	Hölzel, Michael, Burger, Kaspar, Mühl, Bastian, Orban, Mathias, Kellner, Markus, Eick, Dirk
Format:	Online
Language:	English
Published:	Impact Journals LLC 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053546/

id	pubmed-4053546
recordtype	oai_dc
spelling	pubmed-40535462014-06-17 The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword Hölzel, Michael Burger, Kaspar Mühl, Bastian Orban, Mathias Kellner, Markus Eick, Dirk Research Perspective Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected. Impact Journals LLC 2010-05-01 /pmc/articles/PMC4053546/ /pubmed/21293052 Text en Copyright: © 2010 Hölzel et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hölzel, Michael Burger, Kaspar Mühl, Bastian Orban, Mathias Kellner, Markus Eick, Dirk
spellingShingle	Hölzel, Michael Burger, Kaspar Mühl, Bastian Orban, Mathias Kellner, Markus Eick, Dirk The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
author_facet	Hölzel, Michael Burger, Kaspar Mühl, Bastian Orban, Mathias Kellner, Markus Eick, Dirk
author_sort	Hölzel, Michael
title	The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
title_short	The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
title_full	The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
title_fullStr	The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
title_full_unstemmed	The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
title_sort	tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
description	Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.
publisher	Impact Journals LLC
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053546/
_version_	1612099705914785792

The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword

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