P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, Pten and Ink4a/Arf mutations, and the secondary GBM subtype evolves...

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Bibliographic Details
Main Authors: Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C., Hiller, David J., Chen, An-Jou, Perry, Samuel R., Tonon, Giovanni, Chu, Gerald C., Ding, Zhihu, Stommel, Jayne M., Dunn, Katherine L., Wiedemeyer, Ruprecht, You, Mingjian J., Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L., Wong, Wing H., Chin, Lynda, DePinho, Ronald A.
Format: Online
Language:English
Published: 2008
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051433/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051433/

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