Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

In human cells, the RIPK1–RIPK3–MLKL–PGAM5–Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence and functionality of the reported necroptotic...

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Bibliographic Details
Main Authors: Remijsen, Q, Goossens, V, Grootjans, S, Van den Haute, C, Vanlangenakker, N, Dondelinger, Y, Roelandt, R, Bruggeman, I, Goncalves, A, Bertrand, M J M, Baekelandt, V, Takahashi, N, Berghe, T V, Vandenabeele, P
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040672/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040672/

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