RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

Abstract Necroptosis predominates functionally over apoptosis in the pathophysiology of renal ischemia-reperfusion injury (IRI). Inhibition of the core components of the necroptotic pathway—receptor-interacting protein kinase 1 (RIPK1), RIPK3 or mixed lineage kinase domain-like protein (MLKL) reduce...

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Bibliographic Details
Main Authors: Hui Chen, Yulu Fang, Jianfeng Wu, Hong Chen, Zhenhuan Zou, Xiaohong Zhang, Jing Shao, Yanfang Xu
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Cell Death and Disease
Online Access:http://link.springer.com/article/10.1038/s41419-018-0936-8

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http://link.springer.com/article/10.1038/s41419-018-0936-8

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