In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

► We consider current in vitro OECD genotoxicity tests for nanomaterials. ► Ames test does not appear to be suitable for nanomaterial assessment. ► In vitro HPRT and micronucleus assays require nanomaterial specific protocols. ► We recommend a strategic in vitro genotoxicity testing strategy for nan...

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Main Authors: Doak, S.H., Manshian, B., Jenkins, G.J.S., Singh, N.
Format: Online
Language:English
Published: Elsevier 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028084/
id pubmed-4028084
recordtype oai_dc
spelling pubmed-40280842014-05-28 In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines Doak, S.H. Manshian, B. Jenkins, G.J.S. Singh, N. Article ► We consider current in vitro OECD genotoxicity tests for nanomaterials. ► Ames test does not appear to be suitable for nanomaterial assessment. ► In vitro HPRT and micronucleus assays require nanomaterial specific protocols. ► We recommend a strategic in vitro genotoxicity testing strategy for nanomaterials. Elsevier 2012-06-14 /pmc/articles/PMC4028084/ /pubmed/21971291 http://dx.doi.org/10.1016/j.mrgentox.2011.09.013 Text en © 2012 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Doak, S.H.
Manshian, B.
Jenkins, G.J.S.
Singh, N.
spellingShingle Doak, S.H.
Manshian, B.
Jenkins, G.J.S.
Singh, N.
In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
author_facet Doak, S.H.
Manshian, B.
Jenkins, G.J.S.
Singh, N.
author_sort Doak, S.H.
title In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
title_short In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
title_full In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
title_fullStr In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
title_full_unstemmed In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
title_sort in vitro genotoxicity testing strategy for nanomaterials and the adaptation of current oecd guidelines
description ► We consider current in vitro OECD genotoxicity tests for nanomaterials. ► Ames test does not appear to be suitable for nanomaterial assessment. ► In vitro HPRT and micronucleus assays require nanomaterial specific protocols. ► We recommend a strategic in vitro genotoxicity testing strategy for nanomaterials.
publisher Elsevier
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028084/
_version_ 1612091223624908800

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