Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins
NPM1 is a novel modulator of the BER pathway. NPM1 depletion results in BER protein up-regulation; NPM1 has a stimulatory effect on BER capacity and promotes accumulation of BER proteins within nucleoli. Cisplatin leads to redistribution of NPM1 and BER proteins from nucleoli.
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019495/ |